Reference - Detail
RRC ID | 3430 |
---|---|
Author | Grote P, Conradt B. |
Title | The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. |
Journal | Dev Cell |
Abstract |
The Gli-like transcription factor TRA-1 of C. elegans promotes female development by repressing the transcription of male-specific genes. We have found that tra-1 interacts with tra-4, a previously uncharacterized gene that encodes a protein similar to the human proto-oncoprotein and transcriptional repressor PLZF. In this context, the TRA-4 protein functions with NASP-1, a C. elegans homolog of the mammalian histone chaperone NASP, and the histone deacetylase HDA-1. We also found that tra-4 is a member of the synMuv B group of genes, many of which encode homologs of components of the Drosophila Myb-Muv B transcriptional repressor complex, and that several synMuv B genes also promote female development. Based on these results, we propose that male-specific genes are repressed in C. elegans hermaphrodites by the combined action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP, and HDA-1/HDAC, and synMuv B proteins. Similar interactions may function in sex determination and developmental regulation in other species. |
Volume | 11(4) |
Pages | 561-73 |
Published | 2006-10-1 |
DOI | 10.1016/j.devcel.2006.07.015 |
PII | S1534-5807(06)00342-X |
PMID | 17011494 |
MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Embryo, Nonmammalian Female Helminth Proteins / chemistry Helminth Proteins / genetics Helminth Proteins / metabolism* Molecular Sequence Data Sequence Homology, Amino Acid Sex Characteristics* Transcription Factors / genetics Transcription Factors / metabolism* Transgenes |
IF | 10.092 |
Times Cited | 30 |
WOS Category | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
Resource | |
C.elegans | tm1489 tm1374 tm1624 |