論文 - 詳細
| RRC ID | 35520 |
|---|---|
| 著者 | Peil L, Starosta AL, Virumäe K, Atkinson GC, Tenson T, Remme J, Wilson DN. |
| タイトル | Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. |
| ジャーナル | Nat Chem Biol |
| Abstract |
Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA--a modification that is critical for bacterial virulence. Here we show that the currently accepted Escherichia coli EF-P modification pathway is incomplete and lacks a final hydroxylation step mediated by YfcM, an enzyme distinct from deoxyhypusine hydroxylase that catalyzes the final maturation step of eukaryotic initiation factor 5A, the eukaryotic EF-P homolog. |
| 巻・号 | 8(8) |
| ページ | 695-7 |
| 公開日 | 2012-8-1 |
| DOI | 10.1038/nchembio.1001 |
| PII | nchembio.1001 |
| PMID | 22706199 |
| MeSH | Chymotrypsin / chemistry Escherichia coli / genetics Escherichia coli / metabolism* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Gene Expression Regulation, Bacterial / physiology* Lysine / chemistry* Mass Spectrometry Mixed Function Oxygenases / genetics Mixed Function Oxygenases / metabolism* Molecular Structure Peptide Elongation Factors / genetics Peptide Elongation Factors / metabolism* Protein Binding Protein Processing, Post-Translational |
| IF | 12.587 |
| 引用数 | 52 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 原核生物(大腸菌) | NA |