| RRC ID |
36667
|
| Author |
Tang H, Mori Y.
|
| Title |
Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.
|
| Journal |
J Virol
|
| Abstract |
We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry.
|
| Volume |
89(19)
|
| Pages |
10125-9
|
| Published |
2015-10-1
|
| DOI |
10.1128/JVI.01606-15
|
| PII |
JVI.01606-15
|
| PMID |
26202244
|
| PMC |
PMC4577881
|
| MeSH |
Amino Acid Sequence
Amino Acid Substitution
Animals
Cell Line
Crystallography, X-Ray
Herpesvirus 6, Human / pathogenicity
Herpesvirus 6, Human / physiology*
Host-Pathogen Interactions / genetics
Host-Pathogen Interactions / physiology
Humans
Ligands
Mice
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Protein Conformation
Receptors, OX40 / chemistry*
Receptors, OX40 / genetics
Receptors, OX40 / physiology*
Receptors, Virus / chemistry
Receptors, Virus / genetics
Receptors, Virus / physiology
Sequence Homology, Amino Acid
Virus Internalization*
|
| IF |
4.501
|
| Times Cited |
8
|
|
WOS Category
|
VIROLOGY
|
| Resource |
| Cord blood stem cells for research |
研究用ヒト臍帯血幹細胞 |
