Reference - Detail
| RRC ID | 36787 |
|---|---|
| Author | Imamura K, Asai M, Sugamoto K, Matsumoto T, Yamasaki Y, Kamei I, Hattori T, Kishimoto M, Niisaka S, Kubo M, Nishiyama K, Yamasaki M. |
| Title | Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
In this study, we focused on the anti-inflammatory effect of cordycepin, 3'-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin. |
| Volume | 79(6) |
| Pages | 1021-5 |
| Published | 2015-1-1 |
| DOI | 10.1080/09168451.2015.1008977 |
| PMID | 25652735 |
| MeSH | Animals Anti-Inflammatory Agents / metabolism Anti-Inflammatory Agents / pharmacology* Deoxyadenosines / metabolism Deoxyadenosines / pharmacology* Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / biosynthesis* RAW 264.7 Cells |
| IF | 1.516 |
| Times Cited | 7 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CHEMISTRY, APPLIED |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |