Reference - Detail
| RRC ID | 36977 |
|---|---|
| Author | Vong LB, Yoshitomi T, Matsui H, Nagasaki Y. |
| Title | Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer. |
| Journal | Biomaterials |
| Abstract |
Oral chemotherapy is the preferred treatment for colon cancer. However, this strategy faces many challenges, including instability in the gastrointestinal (GI) tract, insufficient bioavailability, low tumor targeting, and severe adverse effects. In this study, we designed a novel redox nanoparticle (RNP(O)) that is an ideal oral therapeutics for colitis-associated colon cancer treatment. RNP(O) possesses nitroxide radicals in the core, which act as reactive oxygen species (ROS) scavengers. Orally administered RNP(O) highly accumulated in colonic mucosa, and specifically internalized in cancer tissues, but less in normal tissues. Despite of long-term oral administration of RNP(O), no noticeable toxicities were observed in major organs of mice. Because RNP(O) effectively scavenged ROS, it significantly suppressed tumor growth after accumulation at tumor sites. Combination of RNP(O) with the conventional chemotherapy, irinotecan, led to remarkably improved therapeutic efficacy and effectively suppressed its adverse effects on GI tract. Therefore, RNP(O) is promising oral nanotherapeutics for cancer therapies. |
| Volume | 55 |
| Pages | 54-63 |
| Published | 2015-7-1 |
| DOI | 10.1016/j.biomaterials.2015.03.037 |
| PII | S0142-9612(15)00315-4 |
| PMID | 25934452 |
| MeSH | Administration, Oral Animals Antineoplastic Agents / chemistry Azoxymethane / administration & dosage Camptothecin / analogs & derivatives Camptothecin / chemistry Cell Line, Tumor Colitis / complications Colitis / therapy* Colonic Neoplasms / complications Colonic Neoplasms / therapy* Dextrans / chemistry Drug Delivery Systems Drug Screening Assays, Antitumor Endoscopy Free Radical Scavengers / chemistry* Inflammation / pathology Irinotecan Male Mice Mice, Inbred ICR Nanomedicine / methods* Nanoparticles / chemistry* Neoplasms, Experimental / therapy Nitrogen Oxides / chemistry Oxidation-Reduction Reactive Oxygen Species / chemistry Sulfates / chemistry |
| IF | 10.317 |
| Times Cited | 40 |
| WOS Category | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| Resource | |
| Human and Animal Cells | Colon-26(RCB2657) |