Reference - Detail
RRC ID | 37487 |
---|---|
Author | Yamamura M, Takizawa H, Nabeshima T. |
Title | Zwitterionic N2O2-Type Protonated Dipyrrin Bearing a Phosphate Anionic Moiety as a pH-Responsive Fluorescence Indicator. |
Journal | Org Lett |
Abstract |
Zwitterionic protonated-dipyrrin 1 bearing a phosphate unit was synthesized from the N2O2-type tetradentate dipyrrin ligand. Compound 1 is in equilibrium with the deprotonated form 1' with a pKa value of 5.8. Compound 1 exhibited a pH-responsive fluorescence under physiological conditions; the fluorescence intensity increased in aqueous media as the pH increased. In living cells, 1 also exhibited emission responsive to pH. Thus, 1 should be applicable as a pH probe for detecting tumor cells. |
Volume | 17(12) |
Pages | 3114-7 |
Published | 2015-6-19 |
DOI | 10.1021/acs.orglett.5b01414 |
PMID | 26042936 |
MeSH | Fluorescent Dyes / chemistry* Hydrogen-Ion Concentration* Ligands Molecular Structure Nitrous Oxide / chemistry* Phosphates / chemistry* Pyrroles / chemical synthesis* Pyrroles / chemistry* Spectrometry, Fluorescence |
IF | 6.091 |
Times Cited | 5 |
WOS Category | CHEMISTRY, ORGANIC |
Resource | |
Human and Animal Cells | HeLa(RCB0007) |