Reference - Detail
| RRC ID | 390 |
|---|---|
| Author | Bae YK, Shimizu T, Muraoka O, Yabe T, Hirata T, Nojima H, Hirano T, Hibi M. |
| Title | Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. |
| Journal | Gene Expr Patterns |
| Abstract |
sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord. |
| Volume | 4(4) |
| Pages | 481-6 |
| Published | 2004-7-1 |
| DOI | 10.1016/j.modgep.2003.12.001 |
| PII | S1567133X03002254 |
| PMID | 15183316 |
| MeSH | Animals Central Nervous System / embryology* Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology* Homeodomain Proteins / biosynthesis* Homeodomain Proteins / genetics Humans Molecular Sequence Data Nodal Protein Signal Transduction / physiology Transcription Factors / biosynthesis* Transcription Factors / genetics Transforming Growth Factor beta / metabolism Zebrafish / embryology* Zebrafish / genetics Zebrafish Proteins / biosynthesis* Zebrafish Proteins / genetics |
| IF | 0.897 |
| Times Cited | 14 |
| WOS Category | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY |
| Resource | |
| Zebrafish | rw0 |