| RRC ID |
41632
|
| 著者 |
Onoue S, Endo K, Yajima T, Kashimoto K.
|
| タイトル |
Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide attenuate glutamate-induced nNOS activation and cytotoxicity.
|
| ジャーナル |
Regul Pept
|
| Abstract |
Both vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) act as neurotransmitters in the central and peripheral nervous systems. Attention has been focused on these neuropeptides because among their numerous biological activities, they have been confirmed to show neuroprotective effects against ischemia and glutamate-induced cytotoxicity. It is well established that glutamate has excitatory effects on neuronal cells, and that excessive glutamate shows potent neurotoxicity, especially in neuronal nitric oxide synthase-containing neurons. Glutamate stimulates the production of nitric oxide (NO) in neurons, and the NO generated is tightly associated with the delayed death of neurons. We examined the effects of these neuropeptides on the glutamate-induced neural actions using PC12 cells, and we confirmed the important activities of PACAP/VIP on the production of NO as well as the delayed cell death stimulated by glutamate.
|
| 巻・号 |
107(1-3)
|
| ページ |
43-7
|
| 公開日 |
2002-7-15
|
| DOI |
10.1016/s0167-0115(02)00065-4
|
| PII |
S0167011502000654
|
| PMID |
12137965
|
| MeSH |
Animals
Cell Survival
Dose-Response Relationship, Drug
Drug Interactions
Enzyme Activation / drug effects
Enzyme Inhibitors / pharmacology
Glutamic Acid / toxicity
Neuropeptides / chemical synthesis
Neuropeptides / genetics
Neuropeptides / pharmacology*
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase / metabolism
Nitric Oxide Synthase Type I
Nitrites / analysis
PC12 Cells
Pituitary Adenylate Cyclase-Activating Polypeptide
RNA, Messenger / biosynthesis
Rats
Receptors, Vasoactive Intestinal Peptide / biosynthesis
Receptors, Vasoactive Intestinal Peptide / genetics
Vasoactive Intestinal Peptide / chemical synthesis
Vasoactive Intestinal Peptide / pharmacology*
|
| 引用数 |
26
|
|
WOS 分野
|
PHYSIOLOGY
ENDOCRINOLOGY & METABOLISM
|
| リソース情報 |
| ヒト・動物細胞 |
PC-12(RCB0009) |
