| RRC ID |
41697
|
| 著者 |
Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T.
|
| タイトル |
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
|
| ジャーナル |
J Biol Chem
|
| Abstract |
Cytokines in interleukin (IL)-11 subfamily participate in the regulation of bone cell proliferation and differentiation. We report here positive effects of IL-11 on osteoblasts and bone formation. Overexpression of human IL-11 gene in transgenic mice resulted in the stimulation of bone formation to increase cortical thickness and strength of long bones, and in the prevention of cortical bone loss with advancing age. Bone resorption and osteoclastogenesis were not affected in IL-11 transgenic mice. In experiments in vitro, IL-11 stimulated transcription of the target gene for bone morphogenetic protein (BMP) via STAT3, leading to osteoblastic differentiation in the presence of BMP-2, but inhibited adipogenesis in bone marrow stromal cells. These results indicate that IL-11 is a stimulatory factor for osteoblastogenesis and bone formation to conserve cortical bone, possibly by enhancing BMP actions in bone. IL-11 may be a new therapeutic target for senile osteoporosis.
|
| 巻・号 |
277(50)
|
| ページ |
49011-8
|
| 公開日 |
2002-12-13
|
| DOI |
10.1074/jbc.M207804200
|
| PII |
S0021-9258(19)33148-5
|
| PMID |
12384500
|
| MeSH |
Aging / pathology*
Animals
Base Sequence
Bone Development / drug effects*
Bone Marrow Cells / metabolism
Bone Morphogenetic Proteins / genetics
Bone Morphogenetic Proteins / physiology
Bone Resorption / prevention & control*
Cells, Cultured
Chromans / pharmacology
DNA Primers
Humans
Interleukin-11 / pharmacology*
Male
Mice
Mice, Transgenic
Recombinant Proteins / pharmacology
Thiazoles / pharmacology
Thiazolidinediones*
Transcription, Genetic / drug effects
Troglitazone
|
| IF |
4.238
|
| 引用数 |
96
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
ST2(RCB0224) |
