論文 - 詳細
| RRC ID | 42309 |
|---|---|
| 著者 | Ishii T, Matsuse T, Masuda M, Teramoto S. |
| タイトル | The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells. |
| ジャーナル | Exp Lung Res |
| Abstract |
S-phase kinase-associated protein 2 (SKP2), a member of the F-box family of ubiquitin-protein ligase complexes, controls the stability of cell cycle-related proteins including p27Kip1. The authors examined how the expression level of SKP2 affects the expression level of cell cycle-related proteins, cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells. Overexpression of SKP2 reduced the expression of p27Kip1, cyclin E, and p21Cip1, increased S-phase cells, rescued A549 cells from apoptosis due to adenoviral infection, and also increased chemoresistance against camptothecin, cisplatin, and AG1478. Down-regulation of SKP2 did not affect cell cycle status, and reduced cell viability. |
| 巻・号 | 30(8) |
| ページ | 687-703 |
| 公開日 | 2004-12-1 |
| DOI | 10.1080/01902140490517818 |
| PMID | 15700547 |
| MeSH | Adenocarcinoma / drug therapy Adenocarcinoma / metabolism* Adenocarcinoma / pathology Antineoplastic Agents, Phytogenic / pharmacology Apoptosis Camptothecin / pharmacology Carrier Proteins / metabolism Cell Cycle / physiology* Cell Cycle Proteins / metabolism Cell Line, Tumor Cell Survival / drug effects Cisplatin / pharmacology Cyclin E / metabolism Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Drug Resistance, Neoplasm* Enzyme Inhibitors / pharmacology Humans Intracellular Signaling Peptides and Proteins / metabolism Lung Neoplasms / drug therapy Lung Neoplasms / metabolism* Lung Neoplasms / pathology Quinazolines S-Phase Kinase-Associated Proteins / metabolism* Tyrphostins / pharmacology |
| IF | 1.702 |
| 引用数 | 14 |
| WOS 分野 | RESPIRATORY SYSTEM |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |