論文 - 詳細
| RRC ID | 4250 |
|---|---|
| 著者 | Kawli T, Tan MW. |
| タイトル | Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling. |
| ジャーナル | Nat Immunol |
| Abstract |
Communication between the immune and nervous systems, each of which is able to react rapidly to environmental stimuli, may confer a survival advantage. However, precisely how the nervous system influences the immune response and whether neural modulation of immune function is biologically important are not well understood. Here we report that neuronal exocytosis of neuropeptides from dense core vesicles suppressed the survival of Caenorhabditis elegans and their clearance of infection with the human bacterial pathogen Pseudomonas aeruginosa. This immunomodulatory function was mediated by INS-7, an insulin-like neuropeptide whose induction was associated with Pseudomonas virulence. INS-7 secreted from the nervous system functioned in a non-cell autonomous way to activate the insulin pathway and alter basal and inducible expression of immunity-related genes in intestinal cells. |
| 巻・号 | 9(12) |
| ページ | 1415-24 |
| 公開日 | 2008-12-1 |
| DOI | 10.1038/ni.1672 |
| PII | ni.1672 |
| PMID | 18854822 |
| MeSH | Animals Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / immunology* Caenorhabditis elegans Proteins / metabolism Exocytosis / immunology Immunity, Innate* Insulin / metabolism Neuropeptides / immunology Neuropeptides / metabolism Neurosecretory Systems / immunology* Peptide Hormones / immunology* Peptide Hormones / metabolism Pseudomonas Infections / immunology RNA, Small Interfering Reverse Transcriptase Polymerase Chain Reaction Secretory Vesicles / immunology Secretory Vesicles / metabolism Signal Transduction / immunology* |
| IF | 20.479 |
| 引用数 | 70 |
| WOS 分野 | IMMUNOLOGY |
| リソース情報 | |
| 線虫 | tm1907 |