論文 - 詳細
| RRC ID | 42690 |
|---|---|
| 著者 | Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, McKenzie AN, Nagai H, Hotokebuchi T, Izuhara K. |
| タイトル | Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. |
| ジャーナル | J Allergy Clin Immunol |
| Abstract |
BACKGROUND:Subepithelial fibrosis is a cardinal feature of bronchial asthma. Collagen I, III, and V; fibronectin; and tenascin-C are deposited in the lamina reticularis. Extensive evidence supports the pivotal role of IL-4 and IL-13 in subepithelial fibrosis; however, the precise mechanism remains unclear. We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells. Periostin is thought to be an adhesion molecule because it possesses 4 fasciclin I domains. OBJECTIVE:We explore the possibility that periostin is involved in subepithelial fibrosis in bronchial asthma. METHODS:We analyzed induction of periostin in lung fibroblasts by IL-4 or IL-13. We next analyzed expression of periostin in patients with asthma and in ovalbumin-sensitized and ovalbumin-inhaled mice. Furthermore, we examined the binding ability of periostin to other extracellular matrix proteins. RESULTS:Both IL-4 and IL-13 induced secretion of periostin in lung fibroblasts independently of TGF-beta. Periostin colocalized with other extracellular matrix proteins involved in subepithelial fibrosis in both asthma patients and ovalbumin-sensitized and ovalbumin-inhaled wild-type mice, but not in either IL-4 or IL-13 knockout mice. Periostin had an ability to bind to fibronectin, tenascin-C, collagen V, and periostin itself. CONCLUSION:Periostin secreted by lung fibroblasts in response to IL-4 and/or IL-13 is a novel component of subepithelial fibrosis in bronchial asthma. Periostin may contribute to this process by binding to other extracellular matrix proteins. CLINICAL IMPLICATIONS:Periostin induced by IL-4/IL-13 shows promise in inhibiting subepithelial fibrosis in bronchial asthma. |
| 巻・号 | 118(1) |
| ページ | 98-104 |
| 公開日 | 2006-7-1 |
| DOI | 10.1016/j.jaci.2006.02.046 |
| PII | S0091-6749(06)00644-0 |
| PMID | 16815144 |
| MeSH | Adolescent Adult Aged Aged, 80 and over Animals Asthma / pathology* Bronchi / metabolism Cell Adhesion Molecules / genetics Cell Adhesion Molecules / physiology* Drosophila Epithelium / pathology Extracellular Matrix Proteins / metabolism Fibrosis Humans Interleukin-13 / pharmacology* Interleukin-4 / pharmacology* Mice Mice, Inbred BALB C Middle Aged Ovalbumin / immunology RNA, Messenger / analysis Rabbits |
| IF | 10.228 |
| 引用数 | 427 |
| WOS 分野 | ALLERGY IMMUNOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MRC-5 |