| RRC ID |
42707
|
| 著者 |
Suzuki T, Tazoe H, Taguchi K, Koyama Y, Ichikawa H, Hayakawa S, Munakata H, Isemura M.
|
| タイトル |
DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells.
|
| ジャーナル |
Biomed Res
|
| Abstract |
Using a DNA microarray, we analyzed about 16,600 genes for changes in expression associated with the differentiation of human promyelocytic leukemia HL-60 cells induced by 1alpha,25-dihydroxyvitamin D3 (DVD). Many of the up-regulated genes could be correlated to differentiation-associated changes toward a monocyte/macrophage lineage, and many down-regulated genes could be correlated to repressed cell growth. The present study revealed the down-regulated gene expression of importins and exportins 1, 5, 7, and exportin-tRNA. Thus, the present results confirmed our previous findings of down-regulation of exportin 1 and exportin-tRNA by DVD. Gene expression of exportin 6 is suggested to be regulated differently from that of exportins 1, 5, 7, and exportin-tRNA. The down-regulation of nuclear transport factors may be deeply associated with the differentiation of HL-60 cells induced by DVD.
|
| 巻・号 |
27(3)
|
| ページ |
99-109
|
| 公開日 |
2006-6-1
|
| DOI |
10.2220/biomedres.27.99
|
| PII |
JST.JSTAGE/biomedres/27.99
|
| PMID |
16847355
|
| MeSH |
Calcitriol / pharmacology*
Cell Proliferation
DNA Primers / chemistry
Gene Expression Regulation, Neoplastic*
HL-60 Cells
Humans
Karyopherins / biosynthesis
Karyopherins / metabolism
Leukemia, Promyelocytic, Acute / metabolism*
Macrophages / metabolism
Monocytes / metabolism
Oligonucleotide Array Sequence Analysis / methods*
Reverse Transcriptase Polymerase Chain Reaction
|
| IF |
1.429
|
| 引用数 |
21
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041) |
