Reference - Detail
| RRC ID | 42928 |
|---|---|
| Author | Takadera T, Sakamoto Y, Hizume Y, Ohyashiki T. |
| Title | Cyclosporine A- and FK506-induced apoptosis in PC12 cells. |
| Journal | Cell Biol Toxicol |
| Abstract |
The purpose of this study was to examine, using glycogen synthase kinase (GSK) inhibitors, whether GSK-3 is involved in cyclosporine A (CsA)- and FK506-induced apoptosis in PC12 cells. CsA and FK506 increased apoptotic cell death with morphological changes characterized by cell shrinkage and nuclear condensation or fragmentation. Nerve growth factor (NGF) completely blocked cell death. Caspase-3 activation was accompanied by CsA- and FK506-induced cell death and inhibited by NGF. GSK-3 inhibitors such as alsterpaullone and SB216763 prevented CsA- and FK506-induced apoptosis. These results suggest that CsA and FK506 induce caspase-dependent apoptosis and that GSK-3 activation is involved in CsA- and FK506-induced apoptosis in PC12 cells. |
| Volume | 23(5) |
| Pages | 355-60 |
| Published | 2007-9-1 |
| DOI | 10.1007/s10565-007-0192-7 |
| PMID | 17385075 |
| MeSH | Animals Apoptosis / drug effects* Benzazepines / pharmacology Caspase 3 / metabolism Cyclosporine / pharmacology* Enzyme Activation Glycogen Synthase Kinase 3 / antagonists & inhibitors Immunosuppressive Agents / pharmacology* Indoles / pharmacology Maleimides / pharmacology Nerve Growth Factor / pharmacology PC12 Cells Rats Tacrolimus / pharmacology* |
| IF | 6.284 |
| Times Cited | 7 |
| WOS Category | TOXICOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |