論文 - 詳細
RRC ID | 43504 |
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著者 | Wu H, Yokoyama T, Zhu B, Shimoishi Y, Murata Y, Nakamura Y. |
タイトル | (-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
(-)-Epigallocatechin-3-gallate (EGCG)-induced apoptosis was along both the extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) pathways in Jurkat cells. Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H(2)O(2), both being inhibited by ERK and JNK inhibitors. These results suggest the significant role of mitogen-activated protein kinase (MAPK) signaling in the apoptosis induction regulated by EGCG alone and in combination. |
巻・号 | 72(11) |
ページ | 3034-7 |
公開日 | 2008-11-1 |
DOI | 10.1271/bbb.80422 |
PII | JST.JSTAGE/bbb/80422 |
PMID | 18997418 |
MeSH | Apoptosis / drug effects Catechin / analogs & derivatives* Catechin / pharmacology Humans Hydrogen Peroxide / toxicity* Isothiocyanates / toxicity* Jurkat Cells Mitogen-Activated Protein Kinases / metabolism Signal Transduction / drug effects T-Lymphocytes / drug effects* T-Lymphocytes / metabolism |
IF | 1.516 |
引用数 | 10 |
WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
ヒト・動物細胞 |