論文 - 詳細
| RRC ID | 43628 |
|---|---|
| 著者 | Komizu Y, Ueoka H, Ueoka R. |
| タイトル | Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Hybrid liposomes (HLs), composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether, have selectively inhibited the growth of human hepatocellular carcinoma (HCC) cells without affecting normal hepatocytes to trigger apoptosis via caspase-3 activation. Furthermore, HLs distinguished between the HCC and normal cells which had higher and lower membrane fluidities respectively, then fused and accumulated preferentially into the membranes of HCC cells. It is noteworthy that the anti-cancer activity of HLs correlated well with the fluidity of cell membranes for HCC and other cancer cells. These results suggest that HLs could target cancer cell-membranes in relation to their lipid fluidity that provide the possibility of novel nanotherapy for intractable cancer. |
| 巻・号 | 418(1) |
| ページ | 81-6 |
| 公開日 | 2012-2-3 |
| DOI | 10.1016/j.bbrc.2011.12.134 |
| PII | S0006-291X(11)02343-6 |
| PMID | 22240027 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / metabolism Antineoplastic Agents / pharmacology* Apoptosis / drug effects Carcinoma, Hepatocellular / metabolism* Carcinoma, Hepatocellular / pathology Caspase 3 / metabolism Cell Line, Tumor Cell Membrane / metabolism Cell Membrane / physiology Cell Proliferation / drug effects* Dimyristoylphosphatidylcholine / chemistry* Humans Liposomes / chemistry* Liposomes / metabolism Liposomes / pharmacology* Liver Neoplasms / metabolism* Liver Neoplasms / pathology Membrane Fluidity Nanoparticles Polyethylene Glycols / chemistry* |
| IF | 2.985 |
| 引用数 | 14 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7 Hep G2 |