| RRC ID |
44090
|
| Author |
Huang C, Li W, Ma F, Li Q, Asada Y, Koike K.
|
| Title |
Tinospinosides D, E, and tinospin E, further clerodane diterpenoids from Tinospora sagittata.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-γ activited J774.1 macrophage-like cells was also evaluated.
|
| Volume |
60(10)
|
| Pages |
1324-8
|
| Published |
2012-1-1
|
| DOI |
10.1248/cpb.c12-00482
|
| PII |
DN/JST.JSTAGE/cpb/c12-00482
|
| PMID |
23036973
|
| MeSH |
Animals
Cell Line
Diterpenes, Clerodane / chemistry*
Diterpenes, Clerodane / isolation & purification
Diterpenes, Clerodane / pharmacology*
Interferon-gamma / immunology
Lipopolysaccharides / immunology
Macrophages / drug effects*
Macrophages / immunology
Mice
Models, Molecular
Nitric Oxide / immunology
Plant Roots / chemistry*
Tinospora / chemistry*
|
| IF |
1.416
|
| Times Cited |
13
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
CHEMISTRY, MULTIDISCIPLINARY
|
| Resource |
| Human and Animal Cells |
|
