| RRC ID |
44389
|
| 著者 |
Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI.
|
| タイトル |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion.
|
| ジャーナル |
PLoS One
|
| Abstract |
Tenomodulin (Tnmd) is a type II transmembrane protein characteristically expressed in dense connective tissues such as tendons and ligaments. Its expression in the periodontal ligament (PDL) has also been demonstrated, though the timing and function remain unclear. We investigated the expression of Tnmd during murine tooth eruption and explored its biological functions in vitro. Tnmd expression was related to the time of eruption when occlusal force was transferred to the teeth and surrounding tissues. Tnmd overexpression enhanced cell adhesion in NIH3T3 and human PDL cells. In addition, Tnmd-knockout fibroblasts showed decreased cell adhesion. In the extracellular portions of Tnmd, the BRICHOS domain or CS region was found to be responsible for Tnmd-mediated enhancement of cell adhesion. These results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain.
|
| 巻・号 |
8(4)
|
| ページ |
e60203
|
| 公開日 |
2013-1-1
|
| DOI |
10.1371/journal.pone.0060203
|
| PII |
PONE-D-12-34669
|
| PMID |
23593173
|
| PMC |
PMC3622668
|
| MeSH |
Animals
Cell Adhesion / physiology*
Cell Line, Transformed
Humans
Membrane Proteins / metabolism
Membrane Proteins / physiology*
Mice
NIH 3T3 Cells
Periodontal Ligament / metabolism*
|
| IF |
2.74
|
| 引用数 |
13
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
NIH3T3 |
