論文 - 詳細
| RRC ID | 44418 |
|---|---|
| 著者 | Shimizu K, Asakura M, Shinga J, Sato Y, Kitahara S, Hoshino K, Kaisho T, Schoenberger SP, Ezaki T, Fujii S. |
| タイトル | Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. |
| ジャーナル | J Immunol |
| Abstract |
A key goal of vaccine immunotherapy is the generation of long-term memory CD8(+) T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8(+) T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1(+) dendritic cells (DCs). Generation of CD8(+) memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1(+) and plasmacytoid DCs that was regulated by IFN-α/IFN-αR signals. IFN-α production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy. |
| 巻・号 | 190(11) |
| ページ | 5609-19 |
| 公開日 | 2013-6-1 |
| DOI | 10.4049/jimmunol.1300033 |
| PII | jimmunol.1300033 |
| PMID | 23630347 |
| MeSH | Animals CD8-Positive T-Lymphocytes / immunology* Cell Communication / immunology* Cell Line, Tumor Chemotaxis / immunology Dendritic Cells / immunology* Dendritic Cells / metabolism Immunologic Memory* Interferon Type I / immunology Interferon Type I / metabolism Interleukin-12 / biosynthesis Ligands Mice Natural Killer T-Cells / immunology* Neoplasms / immunology Signal Transduction |
| IF | 4.886 |
| 引用数 | 24 |
| WOS 分野 | IMMUNOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |