| RRC ID |
45288
|
| Author |
Suzuki-Nakagawa C, Nishimura M, Noda M, Iwata H, Hattori M, Ebihara A, Suzuki F, Nakagawa T.
|
| Title |
Intracellular retention of the extracellular domain of the (pro)renin receptor in mammalian cells.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
As a component of the renin-angiotensin system, the (pro)renin receptor [(P)RR] activates prorenin along with intracellular signaling pathways. In this study, the glutathione S-transferase-fused extracellular domain of (P)RR expressed in mammalian cells was recovered in the detergent phase in detergent-based two-phase separation experiments, and intracellular localization was observed by immunocytochemistry, suggesting retention inside the cell through stable membrane association.
|
| Volume |
78(7)
|
| Pages |
1187-90
|
| Published |
2014-1-1
|
| DOI |
10.1080/09168451.2014.915732
|
| PMID |
25229855
|
| MeSH |
Animals
COS Cells
Chlorocebus aethiops
Extracellular Space / metabolism*
Hep G2 Cells
Humans
Intracellular Space / metabolism*
Prorenin Receptor
Protein Structure, Tertiary
Protein Transport
Receptors, Cell Surface / chemistry*
Receptors, Cell Surface / metabolism*
Renin-Angiotensin System
|
| IF |
1.516
|
| Times Cited |
5
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
COS-7(RCB0539) |
