論文 - 詳細
RRC ID | 46539 |
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著者 | Yang CC, Chen D, Lee SS, Walter L. |
タイトル | The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. |
ジャーナル | Aging Cell |
Abstract |
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging. |
巻・号 | 10(4) |
ページ | 724-8 |
公開日 | 2011-8-1 |
DOI | 10.1111/j.1474-9726.2011.00711.x |
PMID | 21463460 |
PMC | PMC3135752 |
MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dynamins / genetics Dynamins / metabolism* Insulin / metabolism* Longevity / physiology Phenotype Signal Transduction |
IF | 7.238 |
引用数 | 35 |
WOS 分野 | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
リソース情報 | |
線虫 | tm1108 |