| RRC ID |
46896
|
| Author |
Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K.
|
| Title |
Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus.
|
| Journal |
Int J Med Microbiol
|
| Abstract |
Aspergillus fumigatus is an all-important pathogenic fungus and is known for its angiotropism. When it invades human organs, A. fumigatus makes direct contact with blood and its components by causing inflammation and invading vascular structures. To learn the effect of its contact with blood on the development of infection, we examined the effect of serum on A. fumigatus growth. In Dulbecco's modified Eagle's medium containing 10% fetal bovine serum, hyphal tip growth was accelerated, forming a thickened and well-networked biofilm associated with extracellular matrix, and fetuin A was identified as the active component in the serum that accelerates fungal growth leading to formation of a community. These results suggest that fetuin A is a novel accelerator of the growth of A. fumigatus and that it participates in the formation of thick biofilm.
|
| Volume |
302(2)
|
| Pages |
108-16
|
| Published |
2012-3-1
|
| DOI |
10.1016/j.ijmm.2011.12.001
|
| PII |
S1438-4221(12)00002-1
|
| PMID |
22293034
|
| MeSH |
Animals
Aspergillus fumigatus / drug effects*
Aspergillus fumigatus / physiology*
Aspergillus fumigatus / ultrastructure
Biofilms / drug effects*
Biofilms / growth & development*
Cattle
Humans
Hyphae / metabolism
Hyphae / ultrastructure
Polysaccharides / metabolism
alpha-2-HS-Glycoprotein / metabolism
alpha-2-HS-Glycoprotein / pharmacology*
|
| IF |
3.113
|
| Times Cited |
12
|
|
WOS Category
|
MICROBIOLOGY
VIROLOGY
|
| Resource |
| Pathogenic microorganisms |
|
