RRC ID |
47713
|
著者 |
Ogura Y, Sasakura Y.
|
タイトル |
Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation.
|
ジャーナル |
Dev Cell
|
Abstract |
During neurulation of chordate ascidians, the 11th mitotic division within the epidermal layer shows a posterior-to-anterior wave that is precisely coordinated with the unidirectional progression of the morphogenetic movement. Here we show that the first sign of this patterned mitosis is an asynchronous anterior-to-posterior S-phase length and that mitotic synchrony is reestablished by a compensatory asynchronous G2-phase length. Live imaging combined with genetic experiments demonstrated that compensatory G2-phase regulation requires transcriptional activation of the G2/M regulator cdc25 by the patterning genes GATA and AP-2. The downregulation of GATA and AP-2 at the onset of neurulation leads to loss of compensatory G2-phase regulation and promotes the transition to patterned mitosis. We propose that such developmentally regulated cell-cycle compensation provides an abrupt switch to spatially patterned mitosis in order to achieve the coordination between mitotic timing and morphogenesis.
|
巻・号 |
37(2)
|
ページ |
148-61
|
公開日 |
2016-4-18
|
DOI |
10.1016/j.devcel.2016.03.013
|
PII |
S1534-5807(16)30158-7
|
PMID |
27093084
|
MeSH |
Animals
Cell Cycle / physiology*
Chordata / metabolism
Ciona intestinalis
G2 Phase / physiology
Mitosis / physiology*
Morphogenesis / physiology*
Neurulation / physiology*
S Phase / physiology
cdc25 Phosphatases / metabolism*
|
IF |
10.092
|
引用数 |
16
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
リソース情報 |
カタユウレイボヤ・(ニッポンウミシダ) |
Wild C. int |