Reference - Detail
RRC ID | 48092 |
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Author | Nawa H, Kotani H, Nakanishi S. |
Title | Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. |
Journal | Nature |
Abstract |
A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner. |
Volume | 312(5996) |
Pages | 729-34 |
Published | 1984-12-20 |
DOI | 10.1038/312729a0 |
PMID | 6083453 |
MeSH | Amino Acid Sequence Animals Base Sequence Cattle Cloning, Molecular Gene Expression Regulation Genes Nerve Tissue Proteins / genetics* Nervous System Physiological Phenomena Peptides / genetics* Protein Precursors / genetics* RNA Splicing* RNA, Messenger / genetics Substance P / genetics* Tachykinins Tissue Distribution |
IF | 42.779 |
Times Cited | 521 |
WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
DNA material | lambda bSP 11 (RDB13171) lambda bSP 15 (RDB13172) lambda bSP 20 (RDB13173) lambda bSP 21 (RDB13174). |