論文 - 詳細
RRC ID | 50412 |
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著者 | Kosakamoto H, Fujisawa Y, Obata F, Miura M. |
タイトル | High expression of A-type lamin in the leading front is required for Drosophila thorax closure. |
ジャーナル | Biochem Biophys Res Commun |
Abstract |
Tissue closure involves the coordinated unidirectional movement of a group of cells without loss of cell-cell contact. However, the molecular mechanisms controlling the tissue closure are not fully understood. Here, we demonstrate that Lamin C, the sole A-type lamin in Drosophila, contributes to the process of thorax closure in pupa. High expression of Lamin C was observed at the leading front of the migrating wing imaginal discs. Live imaging analysis revealed that knockdown of Lamin C in the thorax region affected the coordinated movement of the leading front, resulting in incomplete tissue fusion required for formation of the adult thorax. The closure defect due to knockdown of Lamin C correlated with insufficient accumulation of F-actin at the front. Our study indicates a link between A-type lamin and the cell migration behavior during tissue closure. |
巻・号 | 499(2) |
ページ | 209-214 |
公開日 | 2018-5-5 |
DOI | 10.1016/j.bbrc.2018.03.128 |
PII | S0006-291X(18)30626-0 |
PMID | 29559239 |
MeSH | Actins / metabolism Animals Cell Movement Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / embryology* Drosophila melanogaster / metabolism* Gene Knockdown Techniques Lamin Type A / metabolism* Lamins / genetics Lamins / metabolism* Thorax / cytology Thorax / embryology* |
IF | 2.985 |
引用数 | 0 |
リソース情報 | |
ショウジョウバエ | 10119R-1 10119R-2 |