RRC ID |
51412
|
著者 |
Shen Q, Shi H, Tian C, Ghai V, Liu J.
|
タイトル |
The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm.
|
ジャーナル |
Dev Biol
|
Abstract |
Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory relationships. The single Spalt-like zinc finger containing protein SEM-4/SALL is known to be involved in specifying the proliferative sex myoblast (SM) fate. We have found that SEM-4/SALL is sufficient to promote the SM fate and that it does so in a cell autonomous manner. We further showed that SEM-4/SALL acts through the SoxC transcription factor SEM-2 to promote the SM fate. SEM-2 is known to promote the SM fate by inhibiting the expression of two BWM-specifying transcription factors. In light of recent findings in mammals showing that Sall4, one of the mammalian homologs of SEM-4, contributes to pluripotency regulation by inhibiting differentiation, our work suggests that the function of SEM-4/SALL proteins in regulating pluripotency versus differentiation appears to be evolutionarily conserved.
|
巻・号 |
429(1)
|
ページ |
335-342
|
公開日 |
2017-9-1
|
DOI |
10.1016/j.ydbio.2017.06.011
|
PII |
S0012-1606(17)30310-X
|
PMID |
28614700
|
PMC |
PMC5554739
|
MeSH |
Animals
Caenorhabditis elegans / cytology*
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / metabolism*
Cell Differentiation
Cell Lineage*
Cell Proliferation
DNA-Binding Proteins / metabolism*
Embryo, Nonmammalian / cytology*
Gene Expression Regulation, Developmental
Mesoderm / cytology*
Models, Biological
Mutation / genetics
Regulatory Sequences, Nucleic Acid / genetics
SOXC Transcription Factors / metabolism*
|
IF |
2.896
|
引用数 |
0
|
リソース情報 |
線虫 |
tm547 |