論文 - 詳細
RRC ID | 51620 |
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著者 | Shi YH, Zhu S, Tamura T, Kadowaki M, Wang Z, Yoshimatsu K, Komatsu K. |
タイトル | Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora. |
ジャーナル | J Nat Med |
Abstract |
The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker, β-hexosaminidase release with IC50 values of 40.34 and 25.05 μM, respectively. A primary structure-activity relationship of these components was discussed. |
巻・号 | 70(2) |
ページ | 234-40 |
公開日 | 2016-4-1 |
DOI | 10.1007/s11418-016-0966-4 |
PII | 10.1007/s11418-016-0966-4 |
PMID | 26833191 |
MeSH | Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Biomarkers / metabolism Bridged-Ring Compounds / analysis Cell Line, Tumor Glucosides / isolation & purification Glucosides / pharmacology Glycosides / pharmacology Mast Cells / drug effects* Mast Cells / metabolism Monoterpenes / isolation & purification Monoterpenes / pharmacology Paeonia / chemistry* Paeonia / classification Phytotherapy Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Roots / chemistry Quercetin / isolation & purification Quercetin / pharmacology Rats Species Specificity Structure-Activity Relationship beta-N-Acetylhexosaminidases / metabolism |
IF | 2.055 |
引用数 | 2 |
リソース情報 | |
ヒト・動物細胞 | RBL 2H3(RCB2782) |