論文 - 詳細
| RRC ID | 52440 |
|---|---|
| 著者 | Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A. |
| タイトル | Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. MATERIALS AND METHODS:NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. RESULTS:NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. CONCLUSION:NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction. |
| 巻・号 | 37(11) |
| ページ | 6119-6123 |
| 公開日 | 2017-11-1 |
| DOI | 10.21873/anticanres.12060 |
| PII | 37/11/6119 |
| PMID | 29061792 |
| MeSH | Animals Apoptosis / drug effects Bone Resorption / drug therapy Bone Resorption / metabolism Bone Resorption / pathology* Carcinoma, Squamous Cell / drug therapy Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* Cell Movement / drug effects Cell Proliferation / drug effects Gene Expression Regulation, Neoplastic / drug effects Humans Male Mice Mice, Inbred BALB C Mice, Nude Mouth Neoplasms / drug therapy Mouth Neoplasms / metabolism Mouth Neoplasms / pathology* Prognosis Quinolines / pharmacology Receptors, Neurokinin-3 / antagonists & inhibitors Receptors, Neurokinin-3 / metabolism* Retrospective Studies Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| IF | 1.994 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | HSC-2(RCB1945) |