| RRC ID |
53287
|
| Author |
Sonoda S, Ohta A, Maruo A, Ujisawa T, Kuhara A.
|
| Title |
Sperm Affects Head Sensory Neuron in Temperature Tolerance of Caenorhabditis elegans.
|
| Journal |
Cell Rep
|
| Abstract |
Tolerance to environmental temperature change is essential for the survival and proliferation of animals. The process is controlled by various body tissues, but the orchestration of activity within the tissue network has not been elucidated in detail. Here, we show that sperm affects the activity of temperature-sensing neurons (ASJ) that control cold tolerance in Caenorhabditis elegans. Genetic impairment of sperm caused abnormal cold tolerance, which was unexpectedly restored by impairment of temperature signaling in ASJ neurons. Calcium imaging revealed that ASJ neuronal activity in response to temperature was decreased in sperm mutant gsp-4 with impaired protein phosphatase 1 and rescued by expressing gsp-4 in sperm. Genetic analysis revealed a feedback network in which ASJ neuronal activity regulates the intestine through insulin and a steroid hormone, which then affects sperm and, in turn, controls ASJ neuronal activity. Thus, we propose that feedback between sperm and a sensory neuron mediating temperature tolerance.
|
| Volume |
16(1)
|
| Pages |
56-65
|
| Published |
2016-6-28
|
| DOI |
10.1016/j.celrep.2016.05.078
|
| PII |
S2211-1247(16)30691-X
|
| PMID |
27320929
|
| MeSH |
Adaptation, Physiological*
Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / metabolism
Calcium / metabolism
Cold Temperature*
Head
Intestines / physiology
Male
Models, Biological
Organ Specificity
Receptors, Cell Surface / metabolism
Sensory Receptor Cells / physiology*
Signal Transduction
Spermatozoa / physiology*
Steroids / metabolism
|
| IF |
8.109
|
| Times Cited |
10
|
| Resource |
| C.elegans |
tm2174
tm1185
tm1698
tm699
tm1647
tm5415
tm886
tm1033
tm6661
tm1819 |
