RRC ID |
53925
|
著者 |
Ameku T, Yoshinari Y, Texada MJ, Kondo S, Amezawa K, Yoshizaki G, Shimada-Niwa Y, Niwa R.
|
タイトル |
Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.
|
ジャーナル |
PLoS Biol
|
Abstract |
Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication.
|
巻・号 |
16(9)
|
ページ |
e2005004
|
公開日 |
2018-9-1
|
DOI |
10.1371/journal.pbio.2005004
|
PII |
pbio.2005004
|
PMID |
30248087
|
PMC |
PMC6152996
|
MeSH |
Animals
Base Sequence
Bone Morphogenetic Proteins / metabolism
Cell Count
Cell Division
Cell Proliferation
Digestive System / metabolism*
Drosophila Proteins / metabolism*
Drosophila melanogaster / metabolism*
Ecdysteroids / metabolism
Enteroendocrine Cells / metabolism
Female
Germ Cells / cytology*
Germ Cells / metabolism
Models, Biological
Neuropeptides / metabolism*
Ovary / metabolism
Receptors, Neuropeptide / metabolism
Sexual Behavior, Animal
Signal Transduction
Stem Cells / cytology*
Stem Cells / metabolism*
|
IF |
7.076
|
引用数 |
13
|
リソース情報 |
ショウジョウバエ |
|