RRC ID |
54380
|
著者 |
Matsukage A, Nishikawa K, Ooi T, Seto Y, Yamaguchi M.
|
タイトル |
Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase.
|
ジャーナル |
J Biol Chem
|
Abstract |
Nucleotide sequence analysis of the cDNA and the genomic clones for rat DNA polymerase beta revealed the existence of a 1,005-base pair open reading frame capable of encoding a Mr = 38,269 polypeptide of 335 amino acid residues. The region of 174 amino acid residues between the 42nd and 215th residues of the DNA polymerase beta polypeptide has extensive amino acid sequence homology with the region between the 195th and 366th residues of human terminal deoxynucleotidyltransferase. The two enzymes share extensive homology not only in primary structures but also in the computer-derived higher structures in these particular regions. The genes for DNA polymerase beta and terminal deoxynucleotidyltransferase are proposed to be derived from a common ancestral DNA polymerase gene.
|
巻・号 |
262(19)
|
ページ |
8960-2
|
公開日 |
1987-7-5
|
PII |
S0021-9258(18)48029-5
|
PMID |
3597402
|
MeSH |
Amino Acid Sequence
Animals
DNA Polymerase I / analysis*
DNA Polymerase I / genetics
DNA-Directed DNA Polymerase / analysis*
DNA-Directed DNA Polymerase / genetics
Humans
Macromolecular Substances
Protein Conformation
Rats
|
IF |
4.238
|
引用数 |
73
|
リソース情報 |
遺伝子材料 |
Rat DNA polymerase beta cDNA (RDB01355) |