| RRC ID |
5655
|
| 著者 |
Sinenko SA, Mandal L, Martinez-Agosto JA, Banerjee U.
|
| タイトル |
Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila.
|
| ジャーナル |
Dev Cell
|
| Abstract |
In Drosophila, blood development occurs in a specialized larval hematopoietic organ, the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to multiple blood cell types. Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemocytes. Loss- and gain-of-function analysis indicates that canonical Wg signaling is required for maintenance of prohemocytes and negatively regulates their differentiation. Wg signals locally in a short-range fashion within different compartments of the LG. In addition, Wg signaling positively regulates the proliferation and maintenance of cells that function as a hematopoietic niche in Drosophila, the posterior signaling center (PSC), and in the proliferation of crystal cells. Our studies reveal a conserved function of Wg signaling in the maintenance of stem-like blood progenitors and reveal an involvement of this pathway in the regulation of hemocyte differentiation through its action in the hematopoietic niche.
|
| 巻・号 |
16(5)
|
| ページ |
756-63
|
| 公開日 |
2009-5-1
|
| DOI |
10.1016/j.devcel.2009.03.003
|
| PII |
S1534-5807(09)00093-8
|
| PMID |
19460351
|
| PMC |
PMC2718753
|
| MeSH |
Animals
Cell Proliferation
Drosophila / embryology*
Drosophila Proteins / metabolism*
Embryo, Nonmammalian
Frizzled Receptors / metabolism
Hemocytes / cytology
Hemocytes / metabolism*
Signal Transduction*
Wnt1 Protein / metabolism*
|
| IF |
10.092
|
| 引用数 |
81
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
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