| RRC ID |
56612
|
| Author |
Shuang Z, Mao Y, Lin G, Wang J, Huang X, Chen J, Duan F, Li S.
|
| Title |
Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity.
|
| Journal |
Biomed Res Int
|
| Abstract |
Alpha-L-fucosidase (AFU) has been reported to be a predictor of survival in patients with several cancers, but it is unclear whether AFU is associated with prognosis in patients with intrahepatic cholangiocarcinoma (iCCA). In this study, we used receiver operating characteristic (ROC) analysis to generate the cutoff point of AFU for overall survival (OS). The prognostic influence of the AFU level in serum on OS was studied using Kaplan-Meier curves. Moreover, invasion assays and Western blotting were performed to explore the effects of AFU on iCCA invasion in vitro. We found that higher AFU levels (≥20.85 U/L) were significantly associated with favorable median OS (44.3 months versus 20.1 months; P = 0.022) in iCCA patients. Cox regression models' analyses showed that the AFU level was an independent predictor for OS (P = 0.006). Moreover, our results revealed that the AFU could impair the invasion capability of the iCCA cells, HuH28, and also downregulated the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. In conclusion, our results indicate that AFU is a significantly favorable prognostic factor in iCCA patients.
|
| Volume |
2018
|
| Pages |
8182575
|
| Published |
2018-2-22
|
| DOI |
10.1155/2018/8182575
|
| PMID |
29682557
|
| PMC |
PMC5842738
|
| MeSH |
Bile Duct Neoplasms / blood*
Bile Duct Neoplasms / metabolism
Bile Duct Neoplasms / pathology*
Bile Ducts, Intrahepatic / pathology
Biomarkers, Tumor / blood
Cell Line, Tumor
Cholangiocarcinoma / blood*
Cholangiocarcinoma / metabolism
Cholangiocarcinoma / pathology*
Down-Regulation / physiology
Female
Humans
Male
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 9 / metabolism
Middle Aged
Neoplasm Invasiveness / pathology*
Prognosis
ROC Curve
Retrospective Studies
alpha-L-Fucosidase / blood*
|
| IF |
2.197
|
| Times Cited |
2
|
| Resource |
| Human and Animal Cells |
HuH-28(RCB1943) |
