論文 - 詳細
| RRC ID | 56929 |
|---|---|
| 著者 | Kheawfu K, Pikulkaew S, Hamamoto H, Sekimizu K, Okonogi S. |
| タイトル | Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori). |
| ジャーナル | Drug Discov Ther |
| Abstract |
Clove oil is used in fish anesthesia and expected to have a mechanism via glutamic receptor. The present study explores the activities of clove oil and its major compound, eugenol, in comparison with L-glutamic acid on glutamic receptor of silkworm muscle and fish anesthesia. It was found that clove oil and eugenol had similar effects to L-glutamic acid on inhibition of silkworm muscle contraction after treated with D-glutamic acid and kainic acid. Anesthetic activity of the test samples was investigated in goldfish. The results demonstrated that L-glutamic acid at 20 and 40 mM could induce the fish to stage 3 of anesthesia that the fish exhibited total loss of equilibrium and muscle tone, whereas clove oil and eugenol at 60 ppm could induce the fish to stage 4 of anesthesia that the reflex activity of the fish was lost. These results suggest that clove oil and eugenol have similar functional activities and mechanism to L-glutamic acid on muscle contraction and fish anesthesia. |
| 巻・号 | 11(2) |
| ページ | 64-69 |
| 公開日 | 2017-5-30 |
| DOI | 10.5582/ddt.2017.01012 |
| PMID | 28458297 |
| MeSH | Anesthesia Animals Anti-Infective Agents / pharmacology* Bombyx Clove Oil / pharmacology* Eugenol / pharmacology* Glutamic Acid / pharmacology Goldfish Kainic Acid / pharmacology Muscle Contraction / drug effects* Muscle Tonus / drug effects* Postural Balance / drug effects Receptors, Glutamate Reflex / drug effects |
| 引用数 | 1 |
| リソース情報 | |
| カイコ | |