論文 - 詳細
| RRC ID | 57158 |
|---|---|
| 著者 | Peng J, Santiago IJ, Ahn C, Gur B, Tsui CK, Su Z, Xu C, Karakhanyan A, Silies M, Pecot MY. |
| タイトル | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms. |
| ジャーナル | Elife |
| Abstract |
Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the Drosophila visual system neurons form connections within ten parallel layers. The M3 layer receives input from two neuron types that sequentially innervate M3 during development. Here we show that M3-specific innervation by both neurons is coordinated by Drosophila Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron. We propose that employment of transcriptional modules that cell-intrinsically target neurons to specific layers, and cell-extrinsically recruit other neurons is a general mechanism for building layered networks of neural connections. |
| 巻・号 | 7 |
| 公開日 | 2018-3-7 |
| DOI | 10.7554/eLife.33962 |
| PII | 33962 |
| PMID | 29513217 |
| PMC | PMC5854465 |
| MeSH | Animals Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Gene Expression Regulation, Developmental Medulla Oblongata / growth & development Medulla Oblongata / metabolism Nerve Net / growth & development Netrins / genetics* Neurogenesis / genetics* Neurons / metabolism* Photoreceptor Cells, Invertebrate / metabolism Synapses / genetics Transcription Factors / genetics* Visual Pathways / growth & development |
| IF | 7.551 |
| 引用数 | 5 |
| リソース情報 | |
| ショウジョウバエ | |