論文 - 詳細
RRC ID | 59588 |
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著者 | Schmeisser S, Li S, Bouchard B, Ruiz M, Des Rosiers C, Roy R. |
タイトル | Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. |
ジャーナル | Cell Rep |
Abstract |
A growing body of evidence suggests that changes in fat metabolism may have a significant effect on lifespan. Accumulation of lipid deposits in non-adipose tissue appears to be critical for age-related pathologies and may also contribute to the aging process itself. We established a model of lipid storage in muscle cells of C. elegans to reveal a mechanism that promotes longevity non-cell-autonomously. Here, we describe how muscle-specific activation of adipose triglyceride lipase (ATGL) and the phospholipase A2 (PLA2) ortholog IPLA-7 collectively affect inter-tissular communication and systemic adaptation that requires the activity of AMP-dependent protein kinase (AMPK) and a highly conserved nuclear receptor outside of the muscle. Our data suggest that muscle-specific bioactive lipid signals, or "lipokines," are generated following triglyceride breakdown and that these signals impinge on a complex network of genes that modify the global lipidome, consequently extending the lifespan. |
巻・号 | 29(13) |
ページ | 4540-4552.e8 |
公開日 | 2019-12-24 |
DOI | 10.1016/j.celrep.2019.11.090 |
PII | S2211-1247(19)31588-8 |
PMID | 31875559 |
MeSH | Adenylate Kinase / metabolism Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Diet Enzyme Activation Hydrolysis Lipid Droplets / metabolism Lipidomics* Lipids / chemistry* Lipolysis Longevity / physiology* Muscle Cells / metabolism Muscles / metabolism* Organ Specificity Transcription Factors / metabolism |
IF | 7.815 |
引用数 | 0 |
リソース情報 | |
線虫 | tm1011 |