| RRC ID |
59996
|
| 著者 |
Baxter E, Windloch K, Kelly G, Lee JS, Gannon F, Brennan DJ.
|
| タイトル |
Molecular basis of distinct oestrogen responses in endometrial and breast cancer.
|
| ジャーナル |
Endocr Relat Cancer
|
| Abstract |
Up to 80% of endometrial and breast cancers express oestrogen receptor alpha (ERα). Unlike breast cancer, anti-oestrogen therapy has had limited success in endometrial cancer, raising the possibility that oestrogen has different effects in both cancers. We investigated the role of oestrogen in endometrial and breast cancers using data from The Cancer Genome Atlas (TCGA) in conjunction with cell line studies. Using phosphorylation of ERα (ERα-pSer118) as a marker of transcriptional activation of ERα in TCGA datasets, we found that genes associated with ERα-pSer118 were predominantly unique between tumour types and have distinct regulators. We present data on the alternative and novel roles played by SMAD3, CREB-pSer133 and particularly XBP1 in oestrogen signalling in endometrial and breast cancer.
|
| 巻・号 |
26(1)
|
| ページ |
31-46
|
| 公開日 |
2019-1-1
|
| DOI |
10.1530/ERC-17-0563
|
| PII |
ERC-17-0563
|
| PMID |
30121621
|
| MeSH |
Adult
Aged
Aged, 80 and over
Animals
Breast Neoplasms / metabolism*
Cell Line, Tumor
Cyclic AMP Response Element-Binding Protein / genetics
Cyclic AMP Response Element-Binding Protein / metabolism*
Endometrial Neoplasms / metabolism*
Estrogen Receptor alpha / metabolism*
Estrogens / metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Mice, SCID
Middle Aged
Prognosis
Smad3 Protein / genetics
Smad3 Protein / metabolism*
X-Box Binding Protein 1 / genetics
X-Box Binding Protein 1 / metabolism*
|
| IF |
4.774
|
| 引用数 |
2
|
| リソース情報 |
| ヒト・動物細胞 |
JHUEM-14(RCB2225) |
