RRC ID |
60095
|
著者 |
Leung LC, Wang GX, Madelaine R, Skariah G, Kawakami K, Deisseroth K, Urban AE, Mourrain P.
|
タイトル |
Neural signatures of sleep in zebrafish.
|
ジャーナル |
Nature
|
Abstract |
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.
|
巻・号 |
571(7764)
|
ページ |
198-204
|
公開日 |
2019-7-1
|
DOI |
10.1038/s41586-019-1336-7
|
PII |
10.1038/s41586-019-1336-7
|
PMID |
31292557
|
PMC |
PMC7081717
|
MeSH |
Animals
Biological Evolution
Brain / cytology
Brain / drug effects
Brain / physiology
Brain / physiopathology
Ependyma / cytology
Eye Movements
Fluorescence
Heart Rate
Hypnotics and Sedatives / pharmacology
Hypothalamic Hormones / metabolism
Melanins / metabolism
Neurons / drug effects
Neurons / physiology*
Pigmentation / physiology
Pituitary Hormones / metabolism
Polysomnography / methods
Sleep / drug effects
Sleep / physiology*
Sleep Deprivation / physiopathology
Sleep, REM / drug effects
Sleep, REM / physiology
Sleep, Slow-Wave / drug effects
Sleep, Slow-Wave / physiology
Zebrafish / physiology*
|
IF |
43.07
|
引用数 |
15
|
リソース情報 |
ゼブラフィッシュ |
gSAIzGFFD109A, UAS:GCaMP7a |