RRC ID |
60792
|
著者 |
Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H.
|
タイトル |
Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.
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ジャーナル |
FEBS Lett
|
Abstract |
Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms.
|
巻・号 |
580(9)
|
ページ |
2335-40
|
公開日 |
2006-4-17
|
DOI |
10.1016/j.febslet.2006.03.056
|
PII |
S0014-5793(06)00371-1
|
PMID |
16597440
|
MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal*
Carrier Proteins / genetics*
DNA-Binding Proteins
Disease Models, Animal
Drosophila melanogaster
Frameshift Mutation*
Humans
Intellectual Disability / genetics*
Male
Memory*
Nuclear Proteins / genetics*
Protein Structure, Tertiary / genetics
|
IF |
3.057
|
引用数 |
15
|
リソース情報 |
ショウジョウバエ |
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