| RRC ID |
61582
|
| 著者 |
Nakashima Y, Mima T, Yashiro M, Sonou T, Ohya M, Masumoto A, Yamanaka S, Koreeda D, Tatsuta K, Hanba Y, Moribata M, Negi S, Shigematsu T.
|
| タイトル |
Expression and localization of fibroblast growth factor (FGF)23 and Klotho in the spleen: its physiological and functional implications.
|
| ジャーナル |
Growth Factors
|
| Abstract |
The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220+ CD21/CD35+ CD1d+ CD43- marginal zone B cells. These cells also expressed FGF receptor 1, indicating that Klotho-positive B cells could respond to FGF23. Plasmacytoid dendritic cells (pDCs) with CD11c+ CD45R/B220+ CD11b- CD8α- were found to produce FGF23. Klotho-positive cells and FGF23-producing cells were present in close proximity to each other, suggesting that FGF23 produced by pDCs may act within a limited area. These findings indicate that FGF23-Klotho signaling could play a biological or immunological role in the spleen.
|
| 巻・号 |
34(5-6)
|
| ページ |
196-202
|
| 公開日 |
2016-12-1
|
| DOI |
10.1080/08977194.2016.1273222
|
| PMID |
28095739
|
| MeSH |
Animals
B-Lymphocytes / metabolism
Dendritic Cells / metabolism
Fibroblast Growth Factor-23
Fibroblast Growth Factors / genetics
Fibroblast Growth Factors / metabolism*
Glucuronidase / genetics
Glucuronidase / metabolism*
Klotho Proteins
Male
Mice
Mice, Inbred C57BL
Receptors, Fibroblast Growth Factor / genetics
Receptors, Fibroblast Growth Factor / metabolism
Spleen / cytology
Spleen / metabolism*
|
| IF |
1.543
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
