論文 - 詳細
RRC ID | 61719 |
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著者 | Maeda R, Ida T, Ihara H, Sakamoto T. |
タイトル | Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells. |
巻・号 | 76(5) |
ページ | 1032-4 |
公開日 | 2012-1-1 |
DOI | 10.1271/bbb.120016 |
PII | DN/JST.JSTAGE/bbb/120016 |
PMID | 22738982 |
MeSH | Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / drug effects* Caulerpa / chemistry* Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Chromatin / drug effects Dose-Response Relationship, Drug Female Humans Oligosaccharides / isolation & purification Oligosaccharides / pharmacology* Plant Extracts / chemistry* Poly(ADP-ribose) Polymerase Inhibitors Protein Denaturation Sodium Hydroxide / chemistry Sulfuric Acids / chemistry Xylans / isolation & purification Xylans / pharmacology* |
IF | 1.516 |
リソース情報 | |
ヒト・動物細胞 | NB1RGB(RCB0222) |