論文 - 詳細
RRC ID | 62026 |
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著者 | Narimatsu S, Kobayashi N, Masubuchi Y, Horie T, Kakegawa T, Kobayashi H, Hardwick JP, Gonzalez FJ, Shimada N, Ohmori S, Kitada M, Asaoka K, Kataoka H, Yamamoto S, Satoh T. |
タイトル | Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes. |
ジャーナル | Chem Biol Interact |
Abstract |
We examined and compared enantioselectivity in the oxidation of propranolol (PL) by liver microsomes from humans and Japanese monkeys (Macaca fuscata). PL was oxidized at the naphthalene ring to 4-hydroxypropranolol, 5-hydroxypropranolol and side chain N-desisopropylpropranolol by human liver microsomes with enantioselectivity of [R(+)>S(-)] in PL oxidation rates at substrate concentrations of 10 microM and 1 mM. In contrast, reversed enantioselectivity [R(+) |
巻・号 | 127(1) |
ページ | 73-90 |
公開日 | 2000-6-15 |
DOI | 10.1016/s0009-2797(00)00174-5 |
PII | S0009-2797(00)00174-5 |
PMID | 10903420 |
MeSH | Animals Baculoviridae / genetics Cytochrome P-450 CYP2D6 / genetics Cytochrome P-450 CYP2D6 / metabolism* Humans Hydroxylation Kinetics Macaca Microsomes, Liver / enzymology* Oxidation-Reduction Propranolol / chemistry* Propranolol / metabolism* Recombinant Proteins / metabolism Species Specificity Spodoptera / metabolism Stereoisomerism* Substrate Specificity Transfection |
IF | 3.723 |
リソース情報 | |
ヒト・動物細胞 | Sf9(RCB0563) |