| RRC ID |
62926
|
| 著者 |
Rajan ST, V V AT, Terada-Nakaishi M, Chen P, Hanawa T, Nandakumar AK, Subramanian B.
|
| タイトル |
Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium.
|
| ジャーナル |
Biomed Mater
|
| Abstract |
Surface-modified commercially pure titanium (Cp-Ti) with zirconium (Zr)-based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into the tibiae of rats; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by x-ray diffraction (XRD), transmission electron microscopy and x-ray photoelectron spectroscopy. TFMG- and ZrO2-coated Ti specimens were immersed in simulated body fluid (SBF) for a period of 21 days to evaluate the calcium phosphate precipitation in vitro. XRD, x-ray photoelectron spectroscopy and scanning electron microscopy/energy dispersive x-ray spectroscopy were used to quantify the mineralization on the coated Zr-TFMG and ZrO2. In vitro corrosion studies showed that the Zr-based TFMG and ZrO2 coatings sustained in the SBF, exhibited superior corrosion resistance to the bare crystalline Ti substrate. Wettability studies showed TFMG and ZrO2 coatings with a hydrophobic nature, and the TFMG-coated SBF-submerged specimens showed a hydrophilic nature. The in vitro cell viability of MC3T3-E1 cells showed good cell proliferation and low cytotoxicity. The calcification deposits were evaluated by staining with alizarin red S, which showed a lower calcium formation on Zr-TFMG compared to ZrO2. The present work also aims to assess the assimilation behavior of Cp-Ti, Zr-TFMG and ZrO2 in vivo by inserting the coated specimen in the femur of rats. After post-implantation of 8 weeks, specimens were examined by micro-CT evaluation. The bone contact ratios as calculated were 72.75%, 15.32% and 38.79%. Consequently, the bone affinity was Cp-Ti wire >ZrO2-coated Ti wire >Zr48Cu36Ag8Al8-coated Ti wire.
|
| 巻・号 |
15(6)
|
| ページ |
065019
|
| 公開日 |
2020-10-13
|
| DOI |
10.1088/1748-605X/aba23a
|
| PMID |
32615545
|
| MeSH |
3T3 Cells
Animals
Bone and Bones / drug effects*
Calcium / chemistry
Coated Materials, Biocompatible / chemistry*
Corrosion
Electrochemistry
Glass*
Humans
Materials Testing
Metals / chemistry*
Mice
Microscopy, Electron, Transmission
Photoelectron Spectroscopy
Rats
Stress, Mechanical
Titanium / chemistry*
Wettability
X-Ray Diffraction
X-Ray Microtomography
Zirconium / chemistry*
|
| IF |
3.174
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
