論文 - 詳細
| RRC ID | 6422 |
|---|---|
| 著者 | Stetak A, Hörndli F, Maricq AV, van den Heuvel S, Hajnal A. |
| タイトル | Neuron-specific regulation of associative learning and memory by MAGI-1 in C. elegans. |
| ジャーナル | PLoS One |
| Abstract |
BACKGROUND:Identifying the molecular mechanisms and neural circuits that control learning and memory are major challenges in neuroscience. Mammalian MAGI/S-SCAM is a multi-PDZ domain synaptic scaffolding protein that interacts with a number of postsynaptic signaling proteins and is thereby thought to regulate synaptic plasticity [1], [2], [3]. PRINCIPAL FINDINGS:While investigating the behavioral defects of C. elegans nematodes carrying a mutation in the single MAGI ortholog magi-1, we have identified specific neurons that require MAGI-1 function for different aspects of associative learning and memory. Various sensory stimuli and a food deprivation signal are associated in RIA interneurons during learning, while additional expression of MAGI-1 in glutamatergic AVA, AVD and possibly AVE interneurons is required for efficient memory consolidation, i.e. the ability to retain the conditioned changes in behavior over time. During associative learning, MAGI-1 in RIA neurons controls in a cell non-autonomous fashion the dynamic remodeling of AVA, AVD and AVE synapses containing the ionotropic glutamate receptor (iGluR) GLR-1 [4]. During memory consolidation, however, MAGI-1 controls GLR-1 clustering in AVA and AVD interneurons cell-autonomously and depends on the ability to interact with the beta-catenin HMP-2. SIGNIFICANCE:Together, these results indicate that different aspects of associative learning and memory in C. elegans are likely carried out by distinct subsets of interneurons. The synaptic scaffolding protein MAGI-1 plays a critical role in these processes in part by regulating the clustering of iGluRs at synapses. |
| 巻・号 | 4(6) |
| ページ | e6019 |
| 公開日 | 2009-6-24 |
| DOI | 10.1371/journal.pone.0006019 |
| PMID | 19551147 |
| PMC | PMC2696103 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / physiology* Green Fluorescent Proteins / metabolism Guanylate Kinases / genetics* Guanylate Kinases / physiology* Learning* Memory* Models, Biological Models, Genetic Movement Neuronal Plasticity Neurons / metabolism Neurons / physiology* Promoter Regions, Genetic Signal Transduction Synapses |
| IF | 2.74 |
| 引用数 | 36 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm446 |