RRC ID 65559
著者 Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H.
タイトル Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.
ジャーナル Cell Cycle
Abstract Magnetic hyperthermia (MHT), which combines magnetic nanoparticles (MNPs) with an alternating magnetic field (AMF), holds promise as a cancer therapy. There have been many studies about hyperthermia, most of which have been performed by direct injection of MNPs into tumor tissues. However, there have been no reports of treating peritoneal disseminated disease with MHT to date. In the present study, we treated peritoneal metastasis of gastric cancer with MHT using superparamagnetic iron oxide (Fe3O4) nanoparticle (SPION) coated with carboxydextran as an MNP, in an orthotopic mouse model mimicking early peritoneal disseminated disease of gastric cancer. SPIONs of an optimal size were intraperitoneally administered, and an AMF (390 kHz, 28 kAm-1) was applied for 10 minutes, four times every three days. Three weeks after the first MHT treatment, the peritoneal metastases were significantly inhibited compared with the AMF-alone group or the untreated-control group. The results of the present study show that MHT can be applied as a new treatment option for disseminated peritoneal gastric cancer.Abbreviations: AMF: alternating magnetic field; Cy1: cytology-positive; DMEM: Dulbecco's Modified Eagle's Medium; FBS: fetal bovine serum; H&E: hematoxylin and eosin; HIPEC: hyperthermic intraperitoneal chemotherapy; MEM: Minimum Essential Medium; MHT: magnetic hyperthermia; MNPs: magnetic nanoparticles; P0: macroscopic peritoneal dissemination; RFP: red fluorescent protein; SPION: superparamagnetic iron oxide (Fe3O4) nanoparticle.
巻・号 20(12)
ページ 1122-1133
公開日 2021-6-1
DOI 10.1080/15384101.2021.1919441
PMID 34110969
PMC PMC8265816
MeSH Animals Cell Survival Disease Models, Animal HCT116 Cells Humans Hyperthermia, Induced / methods* Iron / administration & dosage* Luminescent Proteins / metabolism Magnetic Fields* Magnetite Nanoparticles / administration & dosage* Mice Mice, Inbred BALB C Mice, Nude Optical Imaging / methods Oxides / administration & dosage* Peritoneal Neoplasms / secondary* Peritoneal Neoplasms / therapy* Stomach Neoplasms / pathology* Treatment Outcome
IF 3.699
リソース情報
ヒト・動物細胞 GCIY(RCB0555)