論文 - 詳細
| RRC ID | 68800 |
|---|---|
| 著者 | Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K. |
| タイトル | Suprabasin as a novel tumor endothelial cell marker. |
| ジャーナル | Cancer Sci |
| Abstract |
Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker. |
| 巻・号 | 105(12) |
| ページ | 1533-40 |
| 公開日 | 2014-12-1 |
| DOI | 10.1111/cas.12549 |
| PMID | 25283635 |
| PMC | PMC4317965 |
| MeSH | Animals Antigens, Differentiation / genetics Antigens, Differentiation / metabolism* Biomarkers, Tumor / metabolism Cell Line, Tumor Endothelial Cells / metabolism Endothelial Cells / pathology* Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Mice Mice, Nude Neoplasm Metastasis / pathology Neoplasm Proteins / genetics Neoplasm Proteins / metabolism* Neoplasms / metabolism Neoplasms / pathology* Neovascularization, Pathologic / metabolism Signal Transduction |
| IF | 4.966 |
| リソース情報 | |
| ヒト・動物細胞 | OS-RC-2(RCB0735) |