論文 - 詳細
| RRC ID | 7157 |
|---|---|
| 著者 | Iwase T, Uehara Y, Shinji H, Tajima A, Seo H, Takada K, Agata T, Mizunoe Y. |
| タイトル | Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. |
| ジャーナル | Nature |
| Abstract |
Commensal bacteria are known to inhibit pathogen colonization; however, complex host-microbe and microbe-microbe interactions have made it difficult to gain a detailed understanding of the mechanisms involved in the inhibition of colonization. Here we show that the serine protease Esp secreted by a subset of Staphylococcus epidermidis, a commensal bacterium, inhibits biofilm formation and nasal colonization by Staphylococcus aureus, a human pathogen. Epidemiological studies have demonstrated that the presence of Esp-secreting S. epidermidis in the nasal cavities of human volunteers correlates with the absence of S. aureus. Purified Esp inhibits biofilm formation and destroys pre-existing S. aureus biofilms. Furthermore, Esp enhances the susceptibility of S. aureus in biofilms to immune system components. In vivo studies have shown that Esp-secreting S. epidermidis eliminates S. aureus nasal colonization. These findings indicate that Esp hinders S. aureus colonization in vivo through a novel mechanism of bacterial interference, which could lead to the development of novel therapeutics to prevent S. aureus colonization and infection. |
| 巻・号 | 465(7296) |
| ページ | 346-9 |
| 公開日 | 2010-5-20 |
| DOI | 10.1038/nature09074 |
| PII | nature09074 |
| PMID | 20485435 |
| MeSH | Bacterial Proteins / chemistry Bacterial Proteins / isolation & purification Bacterial Proteins / metabolism* Bacterial Proteins / pharmacology Biofilms / growth & development* Female Humans Male Nose / microbiology* Odds Ratio Serine Proteases / chemistry Serine Proteases / deficiency Serine Proteases / isolation & purification Serine Proteases / metabolism* Staphylococcal Infections / microbiology Staphylococcal Infections / prevention & control Staphylococcal Infections / therapy Staphylococcus aureus / growth & development* Staphylococcus aureus / immunology Staphylococcus epidermidis / enzymology* Staphylococcus epidermidis / genetics Staphylococcus epidermidis / physiology* Superinfection / immunology Superinfection / microbiology Superinfection / prevention & control Superinfection / therapy Young Adult beta-Defensins / immunology beta-Defensins / pharmacology |
| IF | 42.779 |
| 引用数 | 420 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| 一般微生物 | JCM 2874 |