RRC ID |
72316
|
著者 |
Saito S, Suzuki S, Arai MA.
|
タイトル |
Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41.
|
ジャーナル |
J Antibiot (Tokyo)
|
Abstract |
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a "heat shock metabolite" (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.
|
巻・号 |
75(9)
|
ページ |
509-513
|
公開日 |
2022-9-1
|
DOI |
10.1038/s41429-022-00551-5
|
PII |
10.1038/s41429-022-00551-5
|
PMID |
35918479
|
MeSH |
Heat-Shock Response
Oxazoles / metabolism
Streptomyces* / metabolism
Thermotolerance*
|
IF |
2.668
|
リソース情報 |
ヒト・動物細胞 |
HL-60(RCB3683) |