| RRC ID |
72657
|
| 著者 |
Zhao T, Xiao Y, Huang B, Ran MJ, Duan X, Wang YF, Lu Y, Yu XQ.
|
| タイトル |
A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis.
|
| ジャーナル |
Cell Death Dis
|
| Abstract |
In Drosophila ovary, niche is composed of somatic cells, including terminal filament cells (TFCs), cap cells (CCs) and escort cells (ECs), which provide extrinsic signals to maintain stem cell renewal or initiate cell differentiation. Niche establishment begins in larval stages when terminal filaments (TFs) are formed, but the underlying mechanism for the development of TFs remains largely unknown. Here we report that transcription factor longitudinals lacking (Lola) is essential for ovary morphogenesis. We showed that Lola protein was expressed abundantly in TFCs and CCs, although also in other cells, and lola was required for the establishment of niche during larval stage. Importantly, we found that knockdown expression of lola induced apoptosis in adult ovary, and that lola affected adult ovary morphogenesis by suppressing expression of Regulator of cullins 1b (Roc1b), an apoptosis-related gene that regulates caspase activation during spermatogenesis. These findings significantly expand our understanding of the mechanisms controlling niche establishment and adult oogenesis in Drosophila.
|
| 巻・号 |
13(9)
|
| ページ |
756
|
| 公開日 |
2022-9-2
|
| DOI |
10.1038/s41419-022-05195-9
|
| PII |
10.1038/s41419-022-05195-9
|
| PMID |
36056003
|
| PMC |
PMC9440207
|
| MeSH |
Animals
Apoptosis / genetics
Cell Differentiation / genetics
Drosophila* / metabolism
Drosophila Proteins* / genetics
Drosophila Proteins* / metabolism
Drosophila melanogaster / metabolism
Female
Male
Ovary / metabolism
Stem Cell Niche / genetics
Transcription Factors / genetics
Transcription Factors / metabolism
|
| IF |
6.304
|
| リソース情報 |
| ショウジョウバエ |
12052R-1 |
