| RRC ID |
72891
|
| Author |
Ali AM, Mackeen MM, Hamid M, Aun QB, Zauyah Y, Azimahtol HL, Kawazu K.
|
| Title |
Cytotoxicity and electron microscopy of cell death induced by goniothalamin.
|
| Journal |
Planta Med
|
| Abstract |
The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
|
| Volume |
63(1)
|
| Pages |
81-3
|
| Published |
1997-2-1
|
| DOI |
10.1055/s-2006-957611
|
| PMID |
9063100
|
| MeSH |
3T3 Cells
Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Death / drug effects*
Humans
Mice
Microscopy, Electron
Pyrones / pharmacology*
Tumor Cells, Cultured
|
| IF |
2.687
|
| Resource |
| Human and Animal Cells |
HGC-27(RCB0500)
3T3, mouse fibroblast |
